Effects of Antrodia camphorata-Supplemented Diets on the Non-Specific Immune Responses and Disease Resistance of Orange-Spotted Grouper (Epinephelus coioides) against Vibrio alginolyticus and Streptococcus iniae

In Taiwan, the mushroom Antrodia camphorata (AC) is used for medicinal purposes, including cancer prevention and treatment. This study aimed to investigate effect of AC-supplemented diets on innate immunity disease resistance orange-spotted grouper Epinephelus coioides against two bacterial infections—Vibrio alginolyticus Streptococcus iniae. Orange-spotted groupers were fed at 0 (control), 1.5, 3.0, 4.5, 6.0 g kg−1 28 days examined immune responses survival rates V. S. The results showed that cellular humoral parameters, respiratory burst, phagocytic activity, lysozyme activity leukocytes, along with serum alternative complement (ACH50) superoxide dismutase as well interleukin (IL)-4 IL-6, all significantly increased in diets. Groupers containing AC doses higher than 3.0 had better control group 3–18 after or iniae challenge. enhanced may be attributable AC-induced immunity, suggesting utilizing a dietary supplement enhance Vibrio infection.